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. 2023 May 15;8(6):1051–1063. doi: 10.1038/s41564-023-01389-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — (A, B) Infectious virus yield after rVSV/SARS-CoV-2/GFP replication for 2 passages (A) or 4 passages (B) in the presence of each of four anti-hACE2 antibodies, or the anti-RBD antibody C144. The concentrations (in μg/ml) indicated on the X-axis or in the absence of antibody (No). Data are derived from two independent experiments. (C) Inhibition of HIV-1 based pseudotyped virus infection by anti-hACE2 mAbs. Anti-hACE2 antibodies (05H02, 2G7A1, 05B04 and the hybrid antibody 05B04 LC/05D06 HC) were incubated with Huh-7.5 target cells and cells were infected with pseudotypes bearing WT or Q498H spike proteins. Infection was measured using NanoLuc luciferase assays. Mean of two independent titrations is plotted, and IC₅₀ values for each anti-hACE2 antibody virus combination is given below.

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