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. 2023 Mar 27;37(6):4193–4223. doi: 10.1007/s00464-023-09981-0

Table 6.

Robotic scope holders used for flexible endoscopes, by year

Name DOF Manipulation type Actuation method Control type & level of automation Control interface Development stage Year Clinical application
NeoGuide endoscopy system (NeoGuide Systems Inc., USA)a [128131] Steering with natural loop maintained

Electromechanical

motor

Teleoperated

Semi-autonomous

Open console system with joystick

(Computer console shapes according to natural loops of colon)

Commercial (defunct) 2007 (FDA)

Investigational procedure

Colonoscopy

Endotics endoscopy System (Era Endoscopy SRL, Italy) [130, 132, 133] Steering Pneumatic

Teleoperated

Semi-autonomous

(Self-propelling)

Workstation with hand-held console Commercial 2009 (CE)

Investigational procedure

Colonoscopy

Endodrive (ECE Medical systems, Germany) [84, 134, 135] Shaft insertion, retraction Electro-mechanical

Teleoperated

Master–slave

Foot pedal Commercial 2010

Investigational procedure

Colonoscopy, biopsy

Surgery—minimally invasive

Polypectomy

Avicenna Roboflex (ELMED Medical Systems, Türkiye) [136, 137] Forward/backward, insertion/retraction, rotation, deflection Motor

Teleoperated

Master–slave

Console with touchscreen and hand manipulator controls (wheel & joystick) Commercial 2013 (CE)

Investigational procedure

Flexible ureterorenoscopy

Surgery—minimally invasive

Urology (retrograde intrarenal surgery)

Teleflex (University of Twente, Netherlands) [10, 138] 4

Distal tip actuation (up/down, left/right)

Shaft translation, rotation

Motor

Teleoperated

Master–slave

Hand control

Head movements

Research prototype (lab studies) 2013

Surgery—minimally invasive

Transoral gastrointestinal procedures

Aer-O-Scope (GI View, Israel) [139141] Steering Pneumatic

Teleoperated

Semi-autonomous

(Self-navigation)

Open workstation with full joystick control

(Computer algorithm adjusts pressure)

Commercial 2016 (FDA)

Investigational procedure

Colonoscopy

invendoscopy E200 System (invendo medical, Germany)b [29, 142, 143]

180° tip deflection

Tip steering, shaft translation

Electromechanical motor

Teleoperated

Master–slave

Open invendo ScopeController with hand-held joystick Commercial 2016 (FDA)

Surgery—minimally invasive

Colonoscopy

Polypectomies

Gastroscope intervention mechanism (GIM) (Chinese Academy of Sciences, China) [144] 2 Push-pulling, rotating Pneumatic pressure

Teleoperated

Master–slave

Hand control joystick Research prototype (in vivo live animal studies) 2017

Investigational procedure

Gastroscopy

Endoscopic operation robot (EOR) (Kyushu Institute of Technology, Japan) [145, 146] 4 Up/down & left/right angulation, insertion/retraction, rotation Motor

Teleoperated

Master–slave

Hand control mini-joystick & knobs Research prototype (lab studies) 2018

Investigational procedure

Colonoscopy

Surgery—minimally invasive

Endoscopic submucosal dissection (ESD) in porcine model

Robotic-assisted flexible endoscope (RAFE) (Kyushu University, Japan) [127] 4 Up-down, right-left, back–forth, twisting Motor

Teleoperated

Master–slave

One-handle master controller Research prototype (porcine model) 2018

Surgery—minimally invasive

Endoscopic submucosal dissection (ESD)

Sivananthan, Kogkas [147] (NHS & Imperial College London, UK) Steering, advancement, withdrawal, retroflexion Motor

Teleoperated

Master–slave

Eye gaze tracking glasses, head control, joystick (insertion/withdrawal) Research prototype (lab studies) 2021

Surgery—minimally invasive

Endoscopic submucosal dissection (ESD)

aNeoGuide was acquired by Intuitive Surgical Inc., US

bInvendo medical was acquired by Ambu, Denmark