Table 2.

Summary of findings from selected records

Ref	Aims of the study	Summary of findings
[72]	The objectives of the study were to synthesize and characterize AgNP by means of the biomolecule quercetin as a reducing and stabilizing agent. In addition, to isolate and characterize the milk samples carrying the bacteria. And finally, to evaluate the effect of biologically synthesized AgNP on multidrug resistant Gram-negative and Gram-positive bacteria	A nanomaterial-based antimicrobial therapy was designed against P. aeruginosa and S. aureus, strains isolated from milk samples of mastitis-infected goats Successful biomolecule-assisted synthesis of AgNP using quercetin is demonstrated. AgNP were more effective against Gram-negative P. aeruginosa than Gram-positive S. aureus, which could be explained by differences in membrane structure and cell wall composition that influence bacterial accessibility to AgNP -AgNP exert antibacterial effects through loss of membrane stability and inactivation of respiratory chain dehydrogenases, which inhibit cell respiration and growth
[78]	The objective of this study was to evaluate the in vitro activity of AgNP stabilized with different compounds against MDR and Gram-positive and Gram-negative antimicrobial susceptible microorganisms, using different methods	-Different methods were used: agar diffusion, minimum inhibitory concentration, minimum bactericidal concentration and kill time -The activity of AgNP by solid media diffusion and MIC methods showed a similar effect against MDR and antimicrobial susceptible isolates, with a higher effect against Gram-negative strains -The best results were obtained with citrate and chitosan silver nanoparticle
[79]	The objective of the study focuses on the characterization and identification of the most effective marine bacterium against MDR pathogens, to synthesize and characterize AgNP from that strain and to evaluate the efficacy of the resulting AgNP against MDR pathogens	-A rapid method for the synthesis of AgNP was achieved using the halophilic bacterium, Bacillus cereus A30, isolated from marine waters -The AgNP were found to be highly stable and crystalline in nature -The AgNP showed significant activity on the pathogens tested, especially on Gram-negatives
[80]	This research aimed to investigate the medicinal value of G. formosa leaf and flower extracts in terms of antibacterial activity through the synthesis of AgNP against five drug-resistant pathogenic bacteria	-AgNP synthesized from G. formosa leaves and flower extract showed antibacterial activity against Gram-positive (S. aureus, S. mutans, and S. epidermidis) and Gram-negative (K. pneumoniae and P. aeruginosa) bacteria, where Gram-negative bacteria were more sensitive than Gram-positive bacteria
[92]	The aim of this study was to design the rapid biosynthesis of new AgNP with a simple, non-toxic, cost-effective, and environmentally friendly method under ambient conditions using the reduced property of O. gratissimum leaf extract, which shows enhanced efficacy against different Gram positive and Gram-negative bacteria even at low doses	-This study represents a successful synthesis method of AgNP through green synthesis using O. gratissimum leaf extract as a bio-reducer -The antibacterial activity of the particles was tested against multidrug resistant strains of E. coli and S. aureus -AgNPs were shown to exhibit antibacterial activity and were found to be most effective against E. coli (Gram negative) -AgNP was also found to be an effective inhibitor of biofilm formations in both types of strains
[93]	The aim of the present study was to broaden the spectrum of antimicrobial activity of AgNP on clinically isolated human pathogens	The results showed that AgNP caused more rapid bactericidal activity against Gram-negative bacteria than Gram-positive bacteria and possess excellent antimicrobial capacity against important hospital-acquired pathogens -AgNP caused a dramatic effect on their cell membrane resulting in rapid concentration-dependent membrane disruption and bacterial cell lysis, suggesting that these are the main targets of AgNP action in organisms -Mutational resistance to AgNP was not induced when bacteria are sequentially challenged with increasing concentrations of AgNP