Fig. 1.

The effects of antitumor and antifungal drug therapy on immunity during metastasis and proposed mechanisms for the interaction between the pathogenic fungus Cryptococcus spp. and its capsular polysaccharides during tumor progression. MMP, matrix metalloproteinase; EMT, epithelial-mesenchymal transition; ABC transporters, ATP-binding cassette transporters. Green arrows indicate activation and induction effects; red arrows indicate regulation and inhibition effects; gray arrows indicate proposed effects. Upside and downside arrows indicate respectively upregulation and downregulation of indicated factors