Table 2.
Mean values and standard deviations for primary outcomes at baseline, 18, and 24 months. Change scores and adjacent between group effect sizes are also presented.
| Baseline |
18 months |
24 months |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| iCAN-DO (n = 120) |
SC (n = 118) |
iCAN-DO (n = 120) |
SC (n = 118) |
ES |
iCAN-DO (n = 119) |
SC (n = 117) |
ES |
|||||
| M (SD) | M (SD) | M (SD) | Δ BL (SD) | M (SD) | Δ BL (SD) | d | M (SD) | Δ BL (SD) | M (SD) | Δ BL (SD) | d | |
| ITTa | ||||||||||||
| HADS Depression | 8.0 (3.1) | 7.9 (3.7) | 5.2 (3.8) | −2.8 (3.5) | 6.1 (4.6) | −1.8 (3.9) | −0.29⁎ | 5.4 (3.6) | −2.7 (3.5) | 6.2 (4.2) | −1.7 (3.6) | −0.27 |
| HADS Anxiety | 9.1 (3.0) | 10.2 (3.1) | 6.8 (4.0) | −2.3 (3.4) | 8.3 (4.5) | −1.9 (3.7) | −0.13 | 7.1 (4.2) | −2.1 (3.5) | 8.6 (4.3) | −1.6 (3.8) | −0.14 |
| Complete casesb | n = 62 | n = 68 | n = 62 | n = 68 | n = 55 | n = 63 | ||||||
| HADS Depression | 7.5 (3.1) | 8.1 (3.9) | 5.2 (3.7) | −2.3 (3.9) | 6.4 (4.2) | −1.7 (3.6) | −0.18 | 5.6 (3.2) | −2.0 (4.0) | 7.3 (3.8) | −0.9 (3.8) | −0.27 |
| HADS Anxiety | 9.0 (2.6) | 9.6 (3.2) | 7.0 (3.5) | −2.0 (3.4) | 8.6 (4.1) | −1.0 (3.6) | −0.28⁎ | 7.5 (3.7) | −1.3 (3.4) | 9.5 (3.8) | −0.3 (3.7) | −0.27⁎ |
| Per-protocolc | n = 78 | n = 118 | n = 78 | n = 118 | n = 77 | n = 117 | ||||||
| HADS Depression | 7.8 (3.2) | 7.9 (3.7) | 5.4 (3.8) | −2.4 (3.7) | 6.1 (4.6) | −1.8 (3.9) | −0.16 | 5.6 (3.5) | −2.3 (3.6) | 6.2 (4.2) | −1.7 (3.6) | −0.14 |
| HADS Anxiety | 9 (2.7) | 10.2 (3.1) | 7.2 (3.9) | −1.9 (3.4) | 8.3 (4.5) | −1.9 (3.7) | −0.01 | 7.5 (4.1) | −1.6 (3.6) | 8.7 (4.3) | −1.6 (3.8) | −0.01 |
NOTE: A high score represents a higher level of symptoms/problems in all scales. Between group effect sizes (ES) are calculated from baseline to follow-up. A negative ES indicates a lowering of symptoms or function (depending on the measure), and a positive ES indicates an increase.
Abbreviations: HADS = Hospital Anxiety and Depression Scale; ITT = intention-to-treat; BL = baseline; M = mean; SD = standard deviation; CI = confidence intervals.
ITT = intention to treat, including all participants who completed baseline. Data were imputed using last rank carried forward method.
Complete cases = Individuals who completed the assessment and had no missing values.
Per-protocol = In iCAN-DO only participants adherent to the intervention.
Statistically significant intervention effects in the linear mixed model analyses.