. Author manuscript; available in PMC: 2023 Jun 2.

Published in final edited form as: Infection. 2018 Jul 6;46(6):867–870. doi: 10.1007/s15010-018-1174-9

Table 2.

Analysis of the molecular markers of P. falciparum associated with drug resistance

Marker		Pfcrt ^(a)				Pfmdr1 ^(a)					PfK13 ^(b)	Pfdhfr ^(c)			Pfdhps ^(c)					PfCytB ^(d)

codons		74	75	76	97	86	184	1034	1042	1246	580	51	59	108	436	437	540	581	613	268
Wild type		M	N	K	H	N	Y	S	N	D	C	N	C	S	S	A	K	A	A	Y
Wild type		atg	aat	aaa	cac	aat	tat	agt	aat	gat	tgt	aat	tgt	agc	tct	gct	aaa	gcg	gcc	tat

Mutant type		I	E	T	Y	Y	F	C	D	Y	Y	I	R	N	A/F	G	E	G	S/T	S
Mutant type		att	gaa	aca	tac	tat	ttt	tgt	gat	tat	tat	att	cgt	aac	gct/ttt	ggt	gaa	ggg	tcc/acc	tct

Present work	Sample September 29, 2016	I	E	T	H	N	F	S	N	D	C	N	R	N	S	A	E	A	A	Y
	Sample September 29, 2016	att	gaa	aca	cac	aat	ttt	agt	aat	gat	tgt	aat	cgt	aac	tct	gct	gaa	gcg	gcc	tat

	Sample November 3, 2016	I	E	T	H	N	F	S	N	D	C	N	R	N	S	A	E	A	A	Y
	Sample November 3, 2016	att	gaa	aca	cac	aat	ttt	agt	aat	gat	tgt	aat	cgt	aac	tct	gct	gaa	gcg	gcc	tat



*Gobbi, 2016* [12]	Sample November 27, 2014	I	E	T	H	N	Y	S	N	Y	C	N	R	N	S	G	E	A	A	Y
	Sample November 27, 2014	att	gaa	aca	cac	aat	tat	agt	aat	tat	tgt	aat	cgt	aac	tct	ggt	gaa	gcg	gcc	tat

	Sample January 7, 2015	I	E	T	H	N	Y	S	N	Y	C	N	R	N	S	G	E	A	A	Y
	Sample January 7, 2015	att	gaa	aca	cac	aat	tat	agt	aat	tat	tgt	aat	cgt	aac	tct	ggt	gaa	gcg	gcc	tat

Mutations in Pfcrt and Pfmdr1 gene are associated to some quinoline-based antimalarial resistance (e.g., chloroquine)

PfK13 is the molecular markers for artemisinin resistance

Mutations in Pfdhfr/Pfdhps genes are responsible for P. falciparum resistance to antifolate-cycloguanil

Polymorphisms in PfCytB gene were associated to atovaquone resistance