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. 2023 May 19;14:1197709. doi: 10.3389/fimmu.2023.1197709

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Copyright © 2023 Seiler, Kähler, Kleingarn, Sadik, Bieber, Köhl, Ludwig and Karsten

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C5a-mediated in vitro activation of neutrophils from LysM^cre-C5ar2^–/– mice. (A) In vitro chemotaxis of BM cells of LysM^cre-C5ar2^–/– , C5ar2-tdTomato^fl/fl and WT control mice towards C5a (n ≥ 5/group). (B) Neutrophil frequency in the blood of diseased (EBA) LysM^cre-C5ar2^–/– and C5ar2-tdTomato^fl/fl control mice (n = 15/group). (C) C5a-induced increase in CD11b surface expression of LysM^cre-C5ar2^–/– , C5ar2-tdTomato^fl/fl and WT control mice (n ≥ 6/group). * p < 0.05; ns, not significant.