Table 1.
Exosomal miRNAs in HCC.
| Exosomal MiRNA | Parental cells | Recipient cells | Expression | Target gene | Potential Mechanism | Ref. |
|---|---|---|---|---|---|---|
| miR-148a-3p | hepatic stellate cells | HCC cells | down | ITGA5 | suppressing PI3K/AKT pathway | (22) |
| miR-92a-3p | high-metastatic HCC cells | low-metastatic HCC cells | up | PTEN | activating Akt/Snail pathway | (23) |
| miR-199a-3p | mesenchymal stem cells | HCC cells | up | mTOR | inhibiting mTOR pathway | (24) |
| miR-20a-5p | cancer-associated fibroblast | HCC cells | up | LIMA1 | activating Wnt/β-catenin pathway | (25) |
| miR-4800-3p | HCC cells | up | STK25 | activating Hippo pathway | (26) | |
| miR-628-5p | M1 macrophages | HCC cells | up | METTL14 | inhibiting m6A modification of circFUT8 | (27) |
| miR-21-5p | HCC cells | THP-1 cells | up | RhoB | regulating MAPK pathway and inducing macrophage M2 polarization | (28) |
ITGA5, integrin Subunit Alpha 5; LIMA1, LIM domain and actin binding 1; STK25, serine/threonine protein kinase 25; METTL14, methyltransferase-like 14; THP-1, human monocyte-derived leukemia; RhoB, Ras homolog family member B.