Table 4.
MiRNAs as biomarkers of HCC.
| MiRNA | Source | Expression | Clinical application | Diagnostic performance | Prognosis | Ref. | |||
|---|---|---|---|---|---|---|---|---|---|
| AUC | Sensitivity | Specificity | Prognostic indicator | P value | |||||
| miR-223-3p | serum | down | diagnosis, prognostic prediction | 0.81 | 76.7% | 80.0% | OS | P=0.001 | (131) |
| miR-4530 | serum | up | diagnosis, prognostic prediction | 0.77 | 72.0% | 72.7% | OS | P=0.011 | (134) |
| miR-4454 | serum | up | diagnosis, prognostic prediction | 0.74 | 79.0% | 63.0% | OS | P=0.029 | (134) |
| miR-497 | serum | down | diagnosis, prognostic prediction | 0.726 | 74.0% | 66.0% | OS | P=0.040 | (135) |
| miR-1246 | serum | up | diagnosis, prognostic prediction | 0.865 | 82.0% | 80.0% | OS | P=0.040 | (135) |
| miR-768-3p | serum | down | diagnosis, prognostic prediction | 0.908 | 87.3% | 80.0% | OS | P=0.006 | (136) |
| miR-487b | serum | up | diagnosis, prognostic prediction | 0.946 | 88.8% | 90.9% | OS | P=0.003 | (137) |
| miR-22 | serum | down | diagnosis | 0.866 | 89.3% | 68.9% | – | – | (138) |
| miR-10b-5p | exosome | up | diagnosis | 0.932 | 91.1% | 75.0% | – | – | (139) |
| miR-215-5p | exosome | up | prognostic prediction | – | – | – | DFS | P=0.02 | (139) |
| miR-34a | exosome | down | diagnosis, prognostic prediction | 0.664 | 78.3% | 51.7% | OS | P<0.05 | (133) |
| miR-638 | exosome | up | prognostic prediction | – | – | – | DFS | P=0.0197 | (46) |
OS, overall survival; DFS, disease free survival.