Figure 1.

(A) Schematic of the human and murine APOE/C-I/C-IV/C-II gene clusters. Human cluster contains the APOC-I pseudogene. In the multienhancer regions downstream from human and mouse APOE/Apoe genes are located multienhancer elements ME1 in human and ME in mouse clusters. Human and mouse Hepatic Control Regions HCR.1 and HCR are located downstream of C-I. Human APOC-I pseudogene is indicated as C-I′; the pseudogene is a result of APOC-I duplication and does not exist in the mouse cluster. ME2 is a duplicated ME1 and exists only in humans. (B) The nucleotide sequences corresponding to putative LXR response elements with the 4-bp spacer within the human and murine MEs are shown as capital letters. The direct repeats are separated by 4-bp spacers. The locations of these sequences relative to the 5′  end of each ME are given. (C) A diagram of chimeric genes in TR APOE model mice generated at Duke (Sullivan et al., 1997) and Jax Labs (Foley et al., 2022). Detailed explanations are provided in the text.