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. 2023 May 19;14:1071603. doi: 10.3389/fmicb.2023.1071603

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Copyright © 2023 Li, Xu, Wang, Liao, Wei, Xie, Xu, Xu, Xie, Jiang, Huang, Wang, Huang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitory effect of PHI-Der on biofilms. (A) Alpha blue showing biofilm inhibition. (B) Crystal violet showing biofilm expression. (C) Biofilm protein expression. (D) Changes in the relative messenger RNA (mRNA) expression of biofilm-related genes after the administration of PHI-Der. (E) Changes in the relative expression of SLC6A4 mRNA after the administration of PHI-Der (a: cell group; b: cells + PHI-Der group; c: infected cell group; d: infected cell + PHI-Der group). (F) PHI-Der and SLC6A4 molecule docking. *p < 0.05, **p < 0.01, ***p < 0.001.