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. 2023 May 19;10:1127261. doi: 10.3389/fcvm.2023.1127261

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© 2023 Pohl, Göz, Gärtner, Brodehl, Cimen, Saguner, Schulze-Bahr, Walhorn, Anselmetti and Milting.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of the localization of different DSC2 constructs in vitro in HT-1080 cells and hiPSC-derived cardiomyocytes. (A) Different signal peptide (SP) constructs lacking the prodomain (-delPD) show localization with IgG- or Sec-SP but not with wildtype SP. (B) Different SP constructs with DSC2 prodomain (PD). Proper localization was observed when wildtype SP and IgG- or Sec-SP were conjugated to the PD. When lacking the SP (WT-delSP) DSC2 was not integrated in the plasma membrane. (C) Partial primary sequence of the prodomain of DSC2 (aa27-aa100). Conserved amino acids are given in orange. ACM-related variants are bold. ER, Endoplasmic reticulum; GA, Golgi apparatus; PM, Plasma membrane; WT, wildtype DSC2. Pictures of PM, ER and GA were taken from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/).