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. 2023 May 19;13:1115943. doi: 10.3389/fonc.2023.1115943

Figure 2.

Figure 2

(A) Three-dimensional structure of LIMA1 (PDB ID=2Y), from AlphaFold Protein Structure Database (https://alphafold.ebi.ac.uk/). LIMA1 contains a LIM structural domain in the center and multiple actin-binding domains at the lateral end, which is capable of cross-linking and stabilizing a network of stabilized actin filaments. (B) Potential molecules and functional proteins interacting with LIMA1, which can be derived from the search tool STRING (http://www.string-db.org/) for retrieving interacting genes or proteins. DUSP5, Dual Specificity Phosphatase 5; CDH1, Cadherin 1; VCL, Vinculin; CTNND1, Catenin Delta 1; CTNNA1, Catenin Alpha 1; CTNNB1, Catenin Beta 1; SIPA1L1, Signal Induced Proliferation Associated 1 Like 1; CDH17, Cadherin 17; NEXN, Nexilin F-Actin Binding Protein; IFRD2, Interferon Related Developmental Regulator 2.