Skip to main content
. 2023 May 19;14:1173069. doi: 10.3389/fimmu.2023.1173069

Figure 1.

Figure 1

δ-toxin present on the non-tape-stripped skin strongly induced food allergic responses following epicutaneous sensitization to food allergens in a murine model. (A) Experimental design to investigate the occurrence of for food allergy after intragastric administration of OVA in WT mice that had been epicutaneously treated or not with OVA ± δ-toxin once a week for six weeks. Blood samples were taken, and small intestines were isolated on day 56. (B) Frequency of diarrhea in OVA-challenged mice after epicutaneous treatment with OVA ± δ-toxin on the non-tape-stripped skin or after non-treatment. (C–E) Serum levels of (C) OVA-specific IgE, (D) OVA-specific IgG1, and (E) MCPT-1 in the mice after the final administration of OVA. (F) The numbers of jejunum mast cells of the mice after the final administration of OVA. (G) Jejunum sections stained with chloroacetate esterase (scale bars, 100 μm). Mast cells stain red. (B, F) Data are pooled from two independent experiments. (C–E) Data are representative of two independent experiments. Means ± SD have been plotted. *, P < 0.05, **, P < 0.01.