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. 2023 May 19;14:1137089. doi: 10.3389/fimmu.2023.1137089

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Copyright © 2023 Luo, Chen, Pan, Chen, Fan and Wen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EcN improved mitochondrial damage and promoted IL-22 expression in granulosa cells of PCOS mice. (A) Body weight; (B) Estrus cycle determination; (C) Glucose and INS levels; (D) The morphological of ovary was analyzed by HE staining; (E–I) Serum levels of FSH, P, LH, T and IL-22 were detected by ELISA; (J, K) Western blot was used to detect the expression of PR-A, LC3II/I, Beclin 1, p62 and cytochrome C in ovarian tissues; (L) The MMP level in granulosa cells was detected by JC-1 method; (M) The expression of COX4 in granulosa cells was detected by RT-qPCR; (N) Mitochondrial damage in ovarian tissue was observed by electron microscopy (green arrow marked the damaged mitochondria, red arrow marked autophagosomes). *P<0.05 vs Control, #P<0.05 vs DHEA-induced PCOS. All data showed as mean ± SD.