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. 2023 Apr 26;8(2):666–672. doi: 10.1002/epi4.12723

FIGURE 3.

FIGURE 3

Plasma allopregnanolone (ALLO) concentration–time profiles following ALLO (1 mg/kg, IV) alone (A) or when administered 10 min after midazolam (MDZ; 0.2 mg/kg, IV) (B). Noncompartmental pharmacokinetic parameter estimates are shown in the table. Cmax, estimated maximum plasma concentration determined by extrapolation to time 0 using a two‐compartment model simulation with parameters as shown in Table S2; Tlast, time of last measurable concentration; AUClast, area under the concentration–time curve (AUC) from dosing (time 0) to the time of the last measured concentration; AUCt‐∞; AUC from dosing (time 0) extrapolated to infinity; Fraction AUC extrapolated, fraction of total AUC due to the extrapolated AUC.