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. 2023 May 19;14:1175275. doi: 10.3389/fimmu.2023.1175275

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Copyright © 2023 Martins, de Oliveira, Souza, Queiroz-Junior, Lobo, Teixeira, Malacco and Soriani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alcohol-fed mice had higher production of NO, CXCL1 in BALF and plasma 24 hours after pneumococcal infection. After alcohol treatment, mice were infected with S. pneumoniae and 24h hours post infection mice were euthanized, BALF and blood plasma was collected to determine (A) NO production through Griess reaction and for analysis of pró-inflammatory mediators. CXCR2 ligand, chemokine (B) CXCL1 on BALF supernatant and (C) plasma, (D) TNF-α in BALF, (E) CCL2 in BALF and (F) IL-6 in BALF. Data are presented as the mean ± SD (4 to 9 mice per group). *Significantly different (p < 0.05), **Significantly different (p < 0.01) by two-way ANOVA analysis test. ***Significantly different (p < 0.001) by two-way ANOVA analysis test.