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. 2023 May 19;14:1125874. doi: 10.3389/fimmu.2023.1125874

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Copyright © 2023 Kumar and Stewart

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunosurveillance and cancer. The continuous immune surveillance of target organs by immune cells (innate and adaptive immunity) through lymphatics and systemic circulation keeps a check on altered or cancer cells in healthy individuals. This helps to maintain homeostasis by removing altered or cancer cells. However, several factors, including aging, obesity, repeated or chronic infections, and different medications, dysregulate or suppress regular immune surveillance leading to a tumor or cancer development. See text for details.