Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 19;14:1125874. doi: 10.3389/fimmu.2023.1125874

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Kumar and Stewart

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

MDSCs in TME or TIME and their immunometabolism. MDSCs infiltration in TME or TIME supports the immunosuppressive microenvironment. IL-8 and many other TME or TIME-released chemokines support their infiltration. To exert their immunosuppressive function, MDSCs show an increased FAO, OXPHOS, and glycolysis. AMPK increase induces glutamine oxidation to support the TCA cycle. The increased lactate level in TME or TIME favors the immunosuppressive function of MDSCs. For example, MDSCs release immunosuppressive cytokines (TGF-β and IL-10), suppress cytotoxic NK cell activity and promote tumor angiogenesis, growth, proliferation, and metastasis. Additionally, arachidonic acid (AA) metabolism to PGE2 in PMN-MDSCs further supports immunosuppressive TIME.