Figure 8.

T cell subtypes and their immunometabolic reprogramming in the immunosuppressive TME or TIME. Different Th1 and cytotoxic T cells infiltrate initially to care for growing or premalignant tumors. However, the nutrient-deprived TME or TIME and the presence of immunosuppressive myeloid cells alter their function, including immunometabolic reprogramming. For example, CD8⁺ cytotoxic T cells undergo cell death, including ferroptosis. Additionally, Th1 and Th17 cells in the high lactate and nutrient-deprived (glucose and glutamine) TIME polarize to immunosuppressive T_regs. All these events support T cell immunometabolic reprogramming to their tumor-supportive phenotype and function, including CD8+T cell death. Details are mentioned in the text.