FIGURE 10.

Antibacterial and anti-inflammatory activities of CH-copper complex coating catheters. (A) Wound situation after 5 days of subcutaneous implantations of (a) bare silicon, (b) pristine ch-copper, and (c) cu-modified ch-coated rubber catheters on the back of mice. (B) Morphologies of the bacterial colony of E. coli (a–d) and S. aureus (e–h) on the Petri dishes from low to high copper content as a result of the in vitro bactericidal activity value assay. (C) Paraffin section through H&E staining after implantation for 5 days; the implanted catheter induced no noticeable difference and inflammation on the left implanted sites or surrounding regions. Moreover, numerous inflammatory cells infiltrated the uncoated and CH-coated silicon rubbers. In addition, a few inflammatory cells were retrieved from the CH-copper-coated silicon rubber, demonstrating that the CH-copper-coated silicon rubber can significantly reduce the risk of device-associated bacterial colonization on the implant and then the risk of infection. Adapted with permission from Gu et al. (2022) under CC BY version 4.0.