Table 2.

Univariate and multivariate analysis of colon cancer overall survival based on the training cohort.

	Univariate analysis		Multivariate analysis
	Log rank χ2 test	P-value	HR (95%CI)	P-value
Age	85.866	< 0.001		< 0.001
< 65			reference
≥ 65			1.448 (1.315-1.595)
Gender	0.012	0.912	NI
Female
Male
Race	3.420	0.181	NI
White
Black
Other a
Grade	140.085	< 0.001		< 0.001
I			reference
II			0.948 (0.724-1.241)
III			1.365 (1.037-1.796)
IV			1.506 (1.110-2.044)
T stage	285.727	< 0.001		< 0.001
T1			reference
T2			1.586 (0.612-4.109)
T3			1.958 (0.806-4.755)
T4			2.972 (1.222-7.227)
N stage	258.274	< 0.001		< 0.001
N0			reference
N1			1.677 (1.444-4.109)
N2			1.733 (1.478-2.032)
M stage	710.426	< 0.001		< 0.001
M0			reference
M1			3.058 (2.763-3.384)
Surgery	1.028	0.311	NI
No
Yes
Radiotherapy	0.001	0.976	NI
No/unknown
Yes
Chemotherapy	144.422	< 0.001		< 0.001
No/unknown			reference
Yes			0.338 (0.306-0.374)
Tumor size	97.624	<0.001		< 0.001
<3cm			reference
3-5cm			1.121 (0.956-1.315)
>5cm			1.329 (1.133-1.559)
CEA	207.361	< 0.001		< 0.001
Negative/normal			reference
Positive/elevated			1.401 (1.268-1.548)
Insurance	9.125	0.010		0.029
Any Medicaid			reference
Insured			0.880 (0.778-0.995)
Uninsured			1.090 (0.869-1.366)
Marital status	45.317	< 0.001		< 0.001
Married			reference
Unmarried			1.242 (1.136-1.359)

T, Tumor; N, Node; M, Metastasis; CEA, carcinoembryonic antigen; NI, not included in the multivariate survival analysis.

^aother includes American Indian/AK Native, Asian/Pacific Islander and unknowns.