Table 1.
Serum data of miR-33b−/− and miR-33b+/+ mice fed a 45% HFD.
| miR-33b−/− | miR-33b+/+ | ||
|---|---|---|---|
| TP (g/dl) | 5.00 ± 0.08 | 4.81 ± 0.13 | |
| ALB (g/dl) | 3.16 ± 0.05 | 3.13 ± 0.08 | |
| AST (IU/l) | 46.3 ± 2.9 | 91.3 ± 15.6 | ** |
| ALT (IU/l) | 26.2 ± 4.3 | 60.6 ± 14.1 | * |
| ALP (IU/l) | 157.6 ± 8.3 | 213.1 ± 14.5 | ** |
| LDH (IU/l) | 492.7 ± 81.4 | 563.1 ± 101.6 | |
| T-BIL (mg/dl) | 0.074 ± 0.007 | 0.175 ± 0.043 | * |
| T-Cho (mg/dl) | 164.5 ± 6.6 | 84.40 ± 11.3 | *** |
| LDL-C (mg/dl) | 12.3 ± 1.3 | 6.7 ± 0.6 | ** |
| HDL-C (mg/dl) | 77.6 ± 1.0 | 46.4 ± 5.6 | *** |
| TG (mg/dl) | 18.3 ± 1.8 | 10.9 ± 1.0 | ** |
| NEFA (μEq/l) | 612.1 ± 34.2 | 602.7 ± 44.1 | |
| CRE (mg/dl) | 0.09 ± 0.007 | 0.08 ± 0.004 | |
| BUN (mg/dl) | 17.6 ± 0.57 | 16.9 ± 0.58 |
Male mice were fed a 45% HFD from the age of 8 wk for 12 wk. Values are the mean ± S.E.M., n = 10, 11 each; *P < 0.05, **P < 0.01, ***P < 0.001, unpaired t test.