Table 3.
Serum data of miR-33b+/+ mice treated with AMOs.
| Diet | NC | GAN | GAN | GAN | GAN | ||||
|---|---|---|---|---|---|---|---|---|---|
| AMOs | NEG | NEG | anti-miR-33a | anti-miR-33b | anti-miR-33a + b | ||||
| TP (g/dl) | 5.06 ± 0.10 | 5.24 ± 0.09 | 5.31 ± 0.15 | 5.30 ± 0.15 | 5.13 ± 0.06 | ||||
| ALB (g/dl) | 3.33 ± 0.10 | 3.23 ± 0.08 | 3.21 ± 0.11 | 3.23 ± 0.06 | 3.02 ± 0.04 | ||||
| AST (IU/l) | 102.0 ± 13.4 | 725.6 ± 157.3 | *** | 423.4 ± 42.1 | 243.8 ± 72.0 | ## | 260.4 ± 42.9 | ## | |
| ALT (IU/l) | 67.7 ± 24.8 | 749.1 ± 215.0 | ** | 349.0 ± 53.1 | 234.1 ± 68.9 | # | 240.6 ± 46.8 | # | |
| ALP (IU/l) | 314.5 ± 21.3 | 596.4 ± 63.19 | ** | 657.0 ± 57.7 | 357.3 ± 41.9 | ## | 370.1 ± 25.4 | # | |
| LDH (IU/l) | 1,505 ± 49.8 | 4,181 ± 654.0 | *** | 2,777 ± 213.7 | # | 2007 ± 204.1 | ### | 1,493 ± 178.4 | ### |
| ChE (IU/l) | 34.7 ± 1.1 | 49.9 ± 2.7 | *** | 46.4 ± 1.2 | 35.7 ± 2.0 | ### | 38.3 ± 1.6 | ### | |
| T-BIL (mg/dl) | 0.100 ± 0.006 | 0.402 ± 0.113 | * | 0.336 ± 0.086 | 0.076 ± 0.008 | ## | 0.070 ± 0.008 | ## | |
| TBA (μmol/l) | 15.0 ± 9.17 | 83.5 ± 29.6 | * | 51.9 ± 14.0 | 6.0 ± 0.9 | ## | 4.6 ± 0.8 | ## | |
| Fe (μg/dl) | 114.7 ± 9.3 | 192.4 ± 8.2 | *** | 195.1 ± 9.6 | 202.6 ± 11.8 | 177.4 ± 9.7 | |||
| T-Cho (mg/dl) | 63.8 ± 3.6 | 114.5 ± 9.8 | ** | 121.9 ± 12.6 | 186.2 ± 8.6 | ### | 166.5 ± 4.5 | ## | |
| LDL-C (mg/dl) | 6.2 ± 0.3 | 17.9 ± 0.83 | *** | 17.1 ± 0.82 | 23.0 ± 1.5 | # | 18.2 ± 1.1 | ||
| HDL-C (mg/dl) | 44.3 ± 2.3 | 61.5 ± 7.5 | 65.1 ± 8.5 | 99.2 ± 3.5 | ### | 92.0 ± 2.0 | ## | ||
| F-CHO (mg/dl) | 7.8 ± 0.8 | 20.0 ± 0.9 | * | 26.4 ± 3.4 | 38.4 ± 3.3 | ### | 30.5 ± 1.6 | # | |
| TG (mg/dl) | 24.2 ± 2.5 | 18.9 ± 1.2 | 18.1 ± 2.6 | 15.7 ± 1.9 | 9.5 ± 0.6 | # | |||
| NEFA (μEq/l) | 999.5 ± 65.5 | 1,036 ± 88.2 | 1,192 ± 69.6 | 1,065 ± 82.9 | 962.5 ± 41.0 | ||||
| CRE (mg/dl) | 0.11 ± 0.010 | 0.12 ± 0.006 | 0.13 ± 0.007 | 0.13 ± 0.011 | 0.12 ± 0.007 | ||||
| BUN (mg/dl) | 21.3 ± 1.09 | 23.4 ± 0.77 | 23.53 ± 1.12 | 23.7 ± 1.02 | 22.9 ± 0.54 |
Male miR-33b+/+ mice were fed NC or the GAN diet and injected with the indicated AMOs from the age of 8 wk for 12 wk. Values are the mean ± S.E.M., n = 6 for NC and n = 8–10 for the GAN diet each, one-way ANOVA with Turkey’s post hoc test. *P < 0.05, **P < 0.01, and ***P < 0.001, compared with NEG (NC diet). #P < 0.05, ##P < 0.01, and ###P < 0.001, compared with NEG (GAN diet).