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. 2023 May 2;14(3):1395–1409. doi: 10.1002/jcsm.13245

Figure 4.

Figure 4

Faecal microbiota transplantation (FMT) of db/db mice fed normal diet (ND) with milk increased grip strength. (A) Depletion of recipient gut microbiota by antibiotics was performed for 2 weeks from 6 to 8 weeks of age prior to FMT. After 3 days of recovery, FMT was performed twice weekly; 200–300 mg of fresh stool was collected from 16‐week‐old db/db mice fed ND with milk and those without milk, respectively. (B) Changes in the body weight (n = 6). (C) The numbers of rotation in the light and dark phases using the running wheel (n = 6). (D) Results of intraperitoneal glucose tolerance testing (iPGTT; 2 g/kg of body weight) for 15‐week‐old mice and the area under the curve (AUC) analysis (n = 6). Results of insulin tolerance testing (ITT; 0.5 U/kg of body weight) for 15‐week‐old mice and the AUC analysis (n = 6). (E) Absolute and relative grip strength (n = 6). (F) Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride and nonesterified fatty acid (NEFA) levels (n = 6). Data are represented as the mean ± SD values. Data were analysed using paired t‐test. ***P < 0.001 and ****P < 0.0001.