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. 2023 Mar 10;14(3):1365–1380. doi: 10.1002/jcsm.13213

Figure 4.

Figure 4

GHK‐Cu protects against CS‐induced muscle dysfunction in mice. (A) Schematic diagram of the intraperitoneal administration of GHK‐Cu (GHK‐Cu; 0.2 mg/kg or 2 mg/kg body weight every week, 7 weeks; n = 8), or vehicle (PBS every week, 7 weeks; n = 8) in CS‐exposed mice model. (B) Body weight (left) and grip strength (right) in each group. (C) Comparison of representative samples of dissected skeletal muscle (left), including Quad (quadriceps), Gast (gastrocnemius), soleus, TA (tibialis anterior), sol (soleus), and EDL (extensor digitorum longus); the ratios of Gast and Quad muscle weight to body weight (right). (D) Representative H&E staining of myofibre cross‐section of Gast (left), and the muscle cross‐sectional area of Gast muscle fibre (right). (E) Western blot analysis of atrogin‐1, MuRF1, PGC‐1α, and Nrf2 levels in mouse Gast muscle. (F) The levels of GSH, MDA, SOD2, and T‐AOC in mouse Gast muscle; *P < 0.05; **P < 0.01; ***P < 0.001.