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. 2023 May 22;120(22):e2211947120. doi: 10.1073/pnas.2211947120

Fig. 4.

Fig. 4.

Yap/Taz regulates MMP gene expression and nascent protein deposition and remodeling. (A) qRT-PCR analysis of mouse tendon fibroblasts following gain-of-function of Yap/Taz (n = 3 biological replicates). (B) qRT-PCR analysis of mouse tendon fibroblasts following loss-of-function of Yap/Taz (n = 3 biological replicates). (C) qRT-PCR analysis of human tendon fibroblasts following loss-of-function of Yap/Taz (n = 3 biological replicates). (D) Schematic showing approach to examine the role of Yap/Taz and blebbistatin in regulating nascent protein deposition and remodeling. (E) Integrated intensity of nascent protein production of tendon fibroblasts after treatment. Each data point represents nascent protein deposition from a single cell. Data from two biological replicates are grouped together. (F) Representative images from data generated in (E). Scale bar represents 50 µm. *P < 0.05 evaluated by unpaired t test. Error bars represent SD.