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. 2023 Jun 2;30:101597. doi: 10.1016/j.mtchem.2023.101597

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Fig. 3 — Biophysical analysis of Sb#15, Sb#15-His6, and SARS-CoV-2 RBD. Top panels show DLS intensity distribution curves. Sb#15 shows a cumulant hydrodynamic radius (CR) of 1.43 ± 0.12 nm and polydispersity index (PDI) of 0.11 ± 0.02%, His6-Sb#15 shows CR of 2.37 ± 0.04 nm and PDI of 0.11 ± 0.02%, and SARS-CoV-2 RBD shows CR of 6.43 ± 0.05 nm and PDI of 0.34 ± 0.01%. Center panels show the 350_nm/330_nm fluorescence intensity ratio along the thermal denaturation curves of His6-Sb#15, Sb#15-His6, and SARS-CoV-2 RBD. Lower panels show the first derivative of the 350_nm/330_nm fluorescence intensity ratio to determine the transition midpoints (T_m) along the thermal denaturation curves for Sb#15 (T_m = 50.9 °C), Sb#15-His6 (T_m = 49.8 °C), and SARS-CoV-2 RBD (T_m = 47.6 °C). DLS, dynamic light scattering.