Table 4.
Methylation modification and its interaction with various type of lncRNAs in BC studies: m6A → lncRNA and lncRNA → m6A
| Long ncRNA | Expression in BC | Signaling pathway involved | Mechanism of action | References |
|---|---|---|---|---|
| LINC00675 | ↓ | METTL3/LINC00675/miR-513b-5p | Suppression of BC cell proliferation, migration, and invasion | [257] |
| HOTAIR | ↑ | YTHDC1/HOTAIR/PRC2 | Promotion of proliferation and invasion of TNBC cells | [258] |
| LINC00958 | ↑ | METTL3/LINC00958/miR-378a-3p/YY1 | Promotion of BC tumorigenesis | [259] |
| MALAT1 | ↑ | METTL3/MALAT1/miR-26b/HMGA2 | Promotion of EMT, migration and invasion in BC | [260] |
| DLGAP1-AS1 | ↑ | WTAP/DLGAP1-AS1/miR-299-3p | Promotion of adriamycin resistance in BC | [261] |
| LINC00942 | ↑ | LINC00942/METTL14/CXCR4 and CYP1B1 | Acceleration of BC cell proliferation, colony formation, and reduction of BC cell apoptosis | [262] |
| UCA1 | ↑ | UCA1/METTL14/miR-375/SOX12 | Progression of BC | [263] |
| KB-1980E6.3 | ↑ | KB-1980E6.3/IGF2BP1/c-Myc | Maintenance of BCSC stemness under hypoxic conditions | [264] |
Abbreviations: ↑, increased, upregulated; ↓, reduced, downregulated; BBM, breast to brain metastases; BCSCs, breast cancer stem cells