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. 2023 May 18;44(3):525–542. doi: 10.24272/j.issn.2095-8137.2023.025

Table 3. Diagnostic tests preferred for suspected etiology.

Causative agents Diagnostic tests
CSF: Cerebrospinal fluid; EBNA: Epstein-Barr nuclear antigen; RT-PCR: Reverse transcription polymerase chain reaction; VCA: Viral capsid antigen.
HSV-1/2 HSV-1/2 PCR: if negative and highly suspected, repeat within 3–7 days with CSF sent for HSV PCR; if test available, consider HSV CSF IgG and IgM in addition
VZV CSF: VZV IgG
Enterovirus CSF: EV PCR; Sensitivity may be low, if test available, consider throat swab and stool sent for EV PCR
EBV EBV serology: VCA IgG and IgM and EBNA IgG
HHV-6 CSF: HHV-6 PCR/Photoconductive relay
Influenza Culture/Antigen detection/Respiratory secretion PCR
JEV CSF/serum: JEV PCR/CSF: IgM/Serology: IgM
ZIKV/DV/ CHIKV CSF/serum: RT-PCR/CSF: IgM/Serology: IgG and IgM
Measles virus Plasma/CSF serology/CSF: PCR
CMV CSF: PCR/IgM
JCV CSF: RT-PCR/IgM/Serology: IgG and IgM/Plasma antigen
Rabies/ABLV Rabies/ABLV testing: serological analysis of serum and CSF; viral isolation or RT-PCR from saliva; tests for viral antigen or histopathology on either a brain biopsy or full-thickness biopsy of nape of neck