Table 1. Pathological and behavioral characterization of Pink1 KO mice.

PINK1 KO	DAergic neurons	Mitochondria	Motor deficits	Other phenotypes	References
N/A: Not available. DAergic: Dopaminergic. DA: Dopamine. SNpc: Substantia nigra pars compacta.
Deletion of exons 4–7	Unchanged DA numbers and levels of striatal DA/DA receptor	N/A	N/A	Striatal plasticity impairments; Increased excitatory transmission	Feligioni et al., 2016; Kitada et al., 2007
Germline deletion	N/A	Impaired mitochondrial respiration in striatum; Increased larger mitochondria	N/A	Reduced aconitase activity	Gautier et al., 2008
Deletion of exons 4–5	Loss of DA neurons in striatum; impaired DA release	Altered mitochondrial calcium storage	N/A	Aberrant innate immune response	Akundi et al., 2011
Deletion of exons 2–3	No DA neuronal neurodegeneration	Increased mitochondrial fragmentation	No motor deficits observed	Serotonergic neuronal loss	Glasl et al., 2012
G309D-PINK1 mutation	Deficiency of striatal DA, no neurodegeneration	Increased mitochondrial dysfunction with impaired mitochondrial fission	Reduction of locomotor activity	Absence of Lewy bodies in SNpc	Gispert et al., 2009
Deletion of exon 1	N/A	Fragmentation of mitochondria; Increased ROS level; Impaired mitochondrial ATP synthesis	N/A	Impaired calcium homeostasis	Oliveras-Salvá et al., 2014
Deletion of exons 2–3	Reduction of DA in SNpc with neurodegeneration	Increased mitochondrial stress	Impaired motor abilities	N/A	Moisoi et al., 2014