KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Deposited Data
Processed spatial and single-cell transcriptomics data.	This paper.	GEO:GSE22441
Software and Algorithms
SpaceMarkers v0.81	This paper.	doi:10.5281/zenodo.7621285
SpaceMarkers analysis scripts.	This paper.	doi:10.5281/zenodo.7621291
STdeconvolve	MIller et al., 2022	https://github.com/JEFworks-Lab/STdeconvolve
CoGAPS v3.15.2	Sherman et al., 2020	doi:10.18129/B9.bioc.CoGAPS
projectR v1.6.0	Sharma et al., 2022	doi:10.18129/B9.bioc.projectR
GSEA	Subramanian et al., 2005; https://www.gsea-msigdb.org/	GSEA v4.2.3
Seurat v4.1.0	Hao*, Hao*, et al., 2021	Version 4.1.0
Other
Gene sets	www.msigdb.com	MSigDB v7.5.1 (Hallmark, Biocarta, and Kegg)
High resolution figures	This paper.	doi:10.5281/zenodo.7622690