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Prevalence of potential DDIs associated with PPIs use throughout the study period after adjusting for seasonality Fig. 3. Interrupted time series of seasonally adjusted values of DDIs. An increase level followed by a gradual decrease was observed Solid line: trend of DDIs after adjusting for seasonality. Dashed line: trend before adjusting for seasonality. DDIs: drug-drug interactions; PPIs: proton-pump inhibitors.
