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. 2023 May 27;28:206–226. doi: 10.1016/j.bioactmat.2023.05.015

Fig. 2.

Fig. 2

Cell-seeding SIS patches promote functional recovery of murine infarcted hearts. (A) Schematic of study design and the data collection time for echocardiographic analysis. All animals received cyclosporine A from one day before-to day 7 post-implantation. AMI, acute myocardial infarction; MI Ctrl, MI Control. (B) Kaplan–Meier survival curves for MI mice. (C) Representative M-mode images of echocardiography hearts from various groups at day 7 post-MI before the implantation (baseline) and day 28 post-implantation (D28). (D) Echocardiographic analysis of LV function (LVEF, LVFS) and dilation (LVESD, LVEDD). n = 13–16 for each group. All values were mean ± SEM. Two-way ANOVA was used for statistical analyses. **p < 0.01, ***p < 0.001 vs. the MI Ctrl group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. the SIS group. (E–F) LVEF (E) and LVEDD (F) at baseline (day 7 post-MI before the implantation) and D28 post implantation. n = 13–16 for each group. A paired t-test for comparison of cardiac function within groups between baseline and 28-day follow up.