Fig. 3.

Total (model 1) and group-wise (model 2) estimated yearly change of z-scaled memory performance depending on the baseline volume of the ROIs. Adjusted marginal effect estimates [95 %CI] were calculated for specific values to ease interpretation: baseline mean volume of the HC group, −10% and −20% volume. Number of participants (n part.) in the models ranged between 101 and 104. Number of baseline and follow-up observations (n obs.) ranged between 216 and 219. Estimates for the AD group are not shown due to the high number of missing values not at random (MNAR) for follow-up memory assessment. Linear mixed models included age, sex and education as covariates. Abbreviations: AAA = anterior amygdaloidarea, AD = Alzheimer’s disease, CA = cornu ammonis, CATA = corticoamygdaloid transition area, CI = confidence interval, GC-ML-DG = granule cell and molecular layer of the dentate gyrus, HATA = hippocampus-amygdala-transition-area, HC = healthy control, MCI = mild cognitive impairment, obs. = observations, part. = participants, ROI = region of interest, SCD = subjective cognitive decline.