Table 2.
Hub genes of differentially expressed genes in the 3D-printed SW480 model compared with the 2D model
| Upregulated DEGs | Downregulated DEGs | ||
|---|---|---|---|
|
|
|
||
| Hub gene | Function | Hub gene | Function |
| CENPF | Cell apoptosis and cell proliferation | ESR1 | Regulation of estrogen |
|
| |||
| BIRC5 | Apoptosis inhibition | IL4 | Immune regulation and cell repair |
|
| |||
| NCAPG | Cell proliferation | BDNF | Brain-Derived Neurotrophic Factor |
|
| |||
| ASPM | Cell proliferation | HIST1H4F | Histone protein coding |
|
| |||
| CDK1 | Cell proliferation | HIST1H2BJ | Nucleosome assembly |
|
| |||
| TOP2A | Cell proliferation and drug resistance | MMP3 | Cell migration |
|
| |||
| KIF2C | Cell proliferation | CTGF | Cell differentiation and cell adhesion |
|
| |||
| CCNA2 | Cell proliferation | HDAC9 | Transcriptional regulation and cell cycle regulation |
|
| |||
| RRM2 | Cell cycle regulation | BTK | B-cell development |
|
| |||
| KIF20A | Cytokinesis regulation | SPI1 | B-cell development |