Table 3.
Hub genes of differentially expressed genes in the 3D-printed SW480 model compared with the sandwich culture model.
| Upregulated DEGs | Downregulated DEGs | |||
|---|---|---|---|---|
|
|
|
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| Hub gene | Function | Hub gene | Function | |
| STAT1 | Cell apoptosis, cell proliferation | JUN | Cell apoptosis, cell proliferation and immune regulation | |
|
| ||||
| DDX58 | Antiviral innate immune response | ATF3 | Cell apoptosis and cell cycle regulation | |
|
| ||||
| MX1 | Antiviral response | DUSP1 | Cell apoptosis, cell proliferation | |
|
| ||||
| IFIT3 | Cell apoptosis, cell proliferation | FOSB | Cell apoptosis, cell proliferation and cell differentiation | |
|
| ||||
| IFIT1 | Viral replication inhibition and translational initiation | KLF6 | Tumor suppression | |
|
| ||||
| OAS1 | Cell growth and cell apoptosis | CXCL8 | Inflammation regulation, tumor migration, invasion, angiogenesis and metastasis | |
|
| ||||
| RSAD2 | Lipid metabolism | NR4A2 | Regulation of central dopamine neurongenesis | |
|
| ||||
| IFIH1 | Inflammatory response | SERPINE1 | Fibrinolytic inhibition | |
|
| ||||
| OASL | Immune response regulation | CSF2 | Granulocytes and macrophages differentiation | |
|
| ||||
| ISG15 | Cell signaling | CAV1 | Tumor suppression and lipid metabolism | |