Table 4.

Hub genes of differentially expressed genes in the 3D-printed multicellular model compared with the 3D-printed SW480 model.

Upregulated DEGs		Downregulated DEGs
Hub gene	Function	Hub gene	Function
ITGAM	Integrins mediate signaling and cell adhesion	DDX58	Innate immune response
IL1B	Inflammation regulation, cell apoptosis, cell proliferation and cell differentiation	OASL	Cell growth and cell apoptosis
FCGR2A	macrophages cell surface receptor and phagocytosis and clearing of immune complexes	STAT1	Cell apoptosis, cell proliferation
FCGR3A	Immune regulation and antigen-antibody complex clearance	IFIT3	Cell apoptosis, cell proliferation
SPI1	Immune cell development	IFIT1	Viral replication inhibition and translational initiation
CCL2	Immune regulation and inflammatory response	OAS1	Cell growth and cell apoptosis
CD4	Immune regulation and antigen recognition	RSAD2	Lipid metabolism
CYBB	Cytophagy and phagocytize bacteria	MX1	antiviral response
FCGR2B	Regulation of antibody production by B-cells	MX2	antiviral response
ITGB2	Immune regulation, signal transduction and cell adhesion	ISG15	Cell signaling