Table 3.
Associations between baseline LAN and incidence of all thyroid cancer according to cancer stage in the NIH-AARP Diet and Health Study (1996–2011).
| LAN in 1996 | p-trend | Per quintile increase | |||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | |||
| OVERALL | |||||||
| Localized | |||||||
| No. of cases | 91 | 101 | 113 | 105 | 123 | ||
| Model 2 | Ref | 1.17 (0.88, 1.56) | 1.33 (1.00, 1.78) | 1.29 (0.95, 1.74) | 1.58 (1.12, 2.22) | 0.01 | 1.10 (1.02, 1.19) |
| Model 3 | Ref | 1.18 (0.88, 1.57) | 1.34 (1.00, 1.79) | 1.30 (0.96, 1.77) | 1.58 (1.13, 2.23) | 0.01 | 1.11 (1.02, 1.19) |
| Regional/Distant | |||||||
| No. of cases | 29 | 33 | 39 | 54 | 49 | ||
| Model 2 | Ref | 1.14 (0.69, 1.90) | 1.31 (0.79, 2.15) | 1.82 (1.12, 2.96) | 1.77 (1.02, 3.06) | 0.01 | 1.18 (1.04, 1.33) |
| Model 3 | Ref | 1.15 (0.69, 1.90) | 1.31 (0.79, 2.16) | 1.83 (1.12, 2.98) | 1.78 (1.03, 3.09) | 0.01 | 1.18 (1.05, 1.34) |
| WOMEN | |||||||
| Localized | |||||||
| No. of cases | 52 | 60 | 65 | 57 | 91 | ||
| Model 2 | Ref | 1.24 (0.85, 1.81) | 1.37 (0.94, 2.01) | 1.20 (0.80, 1.80) | 1.95 (1.27, 2.99) | 0.01 | 1.14 (1.03, 1.25) |
| Model 3 | Ref | 1.25 (0.86, 1.83) | 1.39 (0.95, 2.04) | 1.22 (0.81, 1.82) | 1.98 (1.29, 3.04) | 0.01 | 1.14 (1.03, 1.26) |
| Regional/Distant | |||||||
| No. of cases | 12 | 11 | 12 | 28 | 23 | ||
| Model 2 | Ref | 0.94 (0.41, 2.14) | 0.96 (0.42, 2.20) | 2.06 (0.99, 4.26) | 1.39 (0.61, 3.17) | 0.10 | 1.17 (0.97, 1.41) |
| Model 3 | Ref | 0.94 (0.41, 2.15) | 0.96 (0.42, 2.19) | 2.05 (0.99, 4.25) | 1.39 (0.61, 3.19) | 0.09 | 1.17 (0.97, 1.41) |
| MEN | |||||||
| Localized | |||||||
| No. of cases | 39 | 41 | 48 | 48 | 32 | ||
| Model 2 | Ref | 1.07 (0.69, 1.68) | 1.27 (0.81, 1.99) | 1.40 (0.88, 2.24) | 1.05 (0.58, 1.89) | 0.38 | 1.06 (0.93, 1.20) |
| Model 3 | Ref | 1.07 (0.69, 1.68) | 1.27 (0.81, 2.00) | 1.40 (0.88, 2.24) | 1.05 (0.58, 1.90) | 0.38 | 1.06 (0.93, 1.20) |
| Regional/Distant | |||||||
| No. of cases | 17 | 22 | 27 | 26 | 26 | ||
| Model 2 | Ref | 1.37 (0.72, 2.62) | 1.74 (0.91, 3.31) | 1.88 (0.96, 3.69) | 2.63 (1.24, 5.58) | 0.01 | 1.25 (1.05, 1.47) |
| Model 3 | Ref | 1.36 (0.71, 2.61) | 1.74 (0.91, 3.32) | 1.88 (0.96, 3.70) | 2.64 (1.24, 5.61) | 0.01 | 1.25 (1.05, 1.48) |
Model 2 (main): Adjusted for variables in Model 1 and race, education, marital status, state of residence and median home value, poverty rate and population density at census tract level.
Model 3: Adjusted for variables in Model 2 and smoking status, physical activity, alcohol consumption, diabetes, BMI, and sleep duration.