Table 4.
Associations between baseline LAN and incidence of all thyroid cancer according to tumor size in the NIH-AARP Diet and Health Study (1996–2011).
| LAN in 1996 | p-trend | Per quintile increase | |||||
|---|---|---|---|---|---|---|---|
| Tumor size | Q1 | Q2 | Q3 | Q4 | Q5 | ||
| ≤1.0 cm | |||||||
| No. of cases | 31 | 39 | 38 | 42 | 45 | ||
| Model 2 | Ref | 1.27 (0.79, 2.06) | 1.27 (0.77, 2.07) | 1.41 (0.85, 2.32) | 1.57 (0.89, 2.75) | 0.13 | 1.10 (0.97, 1.25) |
| Model 3 | Ref | 1.28 (0.79, 2.06) | 1.27 (0.78, 2.08) | 1.41 (0.85, 2.33) | 1.57 (0.89, 2.75) | 0.13 | 1.10 (0.97, 1.25) |
| 1.1–2.0 cm | |||||||
| No. of cases | 22 | 25 | 20 | 24 | 35 | ||
| Model 2 | Ref | 1.14 (0.63, 2.04) | 0.94 (0.50, 1.76) | 1.24 (0.66, 2.30) | 2.03 (1.05, 3.92) | 0.06 | 1.16 (0.99, 1.36) |
| Model 3 | Ref | 1.14 (0.64, 2.05) | 0.94 (0.50, 1.76) | 1.23 (0.66, 2.30) | 2.02 (1.04, 3.90) | 0.06 | 1.16 (0.99, 1.36) |
| 2.1–4.0 cm | |||||||
| No. of cases | 22 | 19 | 31 | 27 | 25 | ||
| Model 2 | Ref | 0.87 (0.47, 1.63) | 1.47 (0.82, 2.61) | 1.33 (0.72, 2.45) | 1.28 (0.63, 2.62) | 0.24 | 1.10 (0.94, 1.29) |
| Model 3 | Ref | 0.89 (0.48, 1.66) | 1.50 (0.84, 2.68) | 1.37 (0.74, 2.53) | 1.33 (0.65, 2.72) | 0.20 | 1.11 (0.95, 1.30) |
| >4.0 cm | |||||||
| No. of cases | 13 | 17 | 22 | 34 | 29 | ||
| Model 2 | Ref | 1.51 (0.73, 3.14) | 1.98 (0.97, 4.04) | 3.34 (1.68, 6.64) | 3.14 (1.44, 6.82) | 0.0003 | 1.36 (1.15, 1.61) |
| Model 3 | Ref | 1.51 (0.72, 3.13) | 1.98 (0.97, 4.05) | 3.36 (1.68, 6.69) | 3.17 (1.46, 6.90) | 0.0003 | 1.36 (1.15, 1.61) |
Model 2 (main): Adjusted for variables in Model 1 and race, education, marital status, state of residence and median home value, poverty rate and population density at census tract level.
Model 3: Adjusted for variables in Model 2 and smoking status, physical activity, alcohol consumption, diabetes, BMI, and sleep duration.