Table 1.
Global Burden of Disease 2019 Enteric and Diarrheal Disease Burden Estimates in Children <5 Years of Age and All Ages
| Pathogen/Disease | Children Aged <5 y | All Ages | ||
|---|---|---|---|---|
| Deaths | DALYs | Deaths | DALYs | |
| Rotavirus | 151 514 (70 588–266 416) | 13 568 166 (6 391 731–23 612 454) | 235 331 (110 221–415 457) | 17 071 346 (8 567 481–29 151 299) |
| Salmonella enterica (combined)a | 111 023 | 9 689 494 | 274 059 | 20 075 278 |
| Shigella | 93 831 (35 860–185 931) | 8 402 887 (3 274 243–16 542 456) | 148 202 (61 975–284 541) | 10 602 910 (4 538 791–20 242 702) |
| Adenovirus | 83 492 (43 914–143 867) | 7 415 744 (3 914 145–12 770 032) | 107 065 (63 519–172 993) | 8 321 445 (4 701 161–14 131 064) |
| Cryptosporidium | 77 523 (15 962–190 426) | 6 862 766 (1 463 118–16 773 435) | 133 423 (26 424–360 303) | 8 170 908 (1 797 798–20 226 898) |
| Campylobacter | 58 911 (24 006–116 236) | 5 324 624 (2 230 951–10 387 448) | 139 080 (47 005–304 635) | 7 307 840 (3 204 436–14 174 900) |
| Cholera | 55 701 (28 044–93 931) | 4 837 150 (2 438 859–8 153 152) | 117 241 (71 090–177 806) | 7 134 552 (4 032 717–11 139 174) |
| iNTSa | 49 869 (27 161–80 009) | 4 318 828 (2 355 108–6 931 248) | 79 046 (43 013–124 207) | 6 114 292 (3 323 425–9 705 739) |
| Norovirus | 43 481 (11 754–99 172) | 3 962 128 (1 192 131–8 842 284) | 135 798 (25 103–303 735) | 6 879 357 (2 085 136–14 198 132) |
| dNTSa | 39 493 (4376–107 810) | 3 500 124 (426 309–9 395 645) | 61 647 (4376–190 566) | 4 269 216 (475 319–12 056 915) |
| Aeromonas | 19 651 (7871–39 046) | 1 744 504 (709 751–3 449 201) | 28 019 (12 945–50 322) | 2 073 448 (932 430–3 883 407) |
| Entamoeba | 19 049 (4952–50 300) | 1 706 349 (448 942–4 485 968) | 33 409 (10 529–82 410) | 2 539 799 (850 865–6 186 972) |
| Typhoid fevera | 18 934 (7228–38 033) | 1 635 423 (625 745–3 279 949) | 110 029 (52 810–191 206) | 8 053 346 (3 864 905–13 925 252) |
| EPEC | 15 844 (7447–29 987) | 1 412 061 (667 888–2 658 679) | 20 613 (10 118–37 221) | 1 679 423 (858 148–3 045 518) |
| ETEC | 12 399 (4983–26 372) | 1 133 338 (466 320–2 389 033) | 39 802 (18 039–76 964) | 1 695 355 (828 589–3 252 268) |
| Paratyphoid fevera | 2727 (844–6588) | 235 120 (72 825–567 486) | 23 337 (9801–45 680) | 1 638 424 (682 263–3 206 062) |
| Clostridioides difficile | 2102 (1306–3218) | 182 179 (113 038–278 999) | 32 134 (28 131–36 549) | 870 814 (722 988–1 052 360) |
Data are presented as No. (95% confidence interval).
Abbreviation: DALYs, disability-adjusted life-years; dNTS, nontyphoidal Salmonella diarrhea; EPEC, enteropathogenic Escherichia coli; ETEC, enterotoxigenic Escherichia coli; iNTS, invasive nontyphoidal Salmonella.
iNTS, dNTS, typhoid fever, and paratyphoid fever contribute to Salmonella enterica (combined) burden.