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. 2023 Mar 14;114(6):2318–2334. doi: 10.1111/cas.15772

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© 2023 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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MicroRNA (miR)‐541‐5p and miR‐3064‐5p overexpression partially impair circular RNA nuclear receptor‐interacting protein 1 (circNRIP1)‐induced promotion of malignant behaviors in papillary thyroid cancer (PTC) cells. (A,B) Pyruvate kinase M2 (PKM2) levels in TPC1 cells analyzed by Western blotting. (C,D) TPC1 cell proliferation analyzed by the CCK‐8 assay. (E–H) Glucose uptake and lactate production in PTC cells analyzed using the Glucose Colorimetric Assay Kit. (I,J) Oxygen consumption rate (OCR) and extra cellular acidification rate (ECAR) analyzed by Seahorse metabolic in TPC1 cells. *p < 0.05, **p < 0.01. NC, non control; OD, optical density; ov‐circNRIP1, overexpression‐circNRIP1.