FIGURE 3.

Four typical oncogenic kinase cascades activated in hepatocellular carcinoma (HCC) mouse models. (A) Whole‐tissue lysates from littermate control and advanced murine HCC specimens were analyzed by western blotting using the indicated Abs. GAPDH is shown as a loading control. The experiments were repeated three times. (B) Schematic summary of the protein expression profile for each tumor model. GSK3β, glycogen synthase kinase 3β; HDAC, histone deacetylase; NF‐κB, nuclear factor‐κB; P‐, phosphorylated; PTEN, phosphatase and tensin homolog; STAT3, signal transducer and activator of transcription 3.