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. 2023 Apr 3;114(6):2386–2399. doi: 10.1111/cas.15788

FIGURE 4.

FIGURE 4

Similarities between signaling pathways in human hepatocellular carcinoma (HCC) samples and HCC mouse models. (A, D) Number of (A) single nucleotide polymorphism (SNP)–insertion/deletion (indel) mutations and (D) copy number variants (CNVs) in specific genes of each HCC sample. Blue, indel mutation; green, CNV loss; orange, CNV gain; red, SNP mutation. (B) Stacked bar chart showing the percentages of mutation distribution for each HCC sample. (C) Genes that were altered in the HCC samples. Blue, SNP‐indel; dual‐color filled lattice, two types of genetic changes occurring simultaneously; gray, no variation; orange, CNV. Pathways to which each of the genes belong are shown below the heatmap. (E) Lysates of tissues from human HCC samples, tumor‐adjacent (adj) normal liver, and benign tissue specimens (Benign pat) were analyzed by western blotting using the indicated Abs. GSK3β, glycogen synthase kinase 3β; HDAC, histone deacetylase; NF‐κB, nuclear factor‐κB; P‐, phosphorylated; Pat, patient; PTEN, phosphatase and tensin homolog; STAT3, signal transducer and activator of transcription 3.