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. 2023 Apr 3;114(6):2386–2399. doi: 10.1111/cas.15788

FIGURE 6.

FIGURE 6

Targeted therapy alters immune infiltration and significantly reduces tumor burden in mice. (A–K) Inhibitors targeting specific signaling pathways in combination with sorafenib significantly suppressed tumor growth in subcutaneous tumor models constructed from mouse primary cell lines. (A, E, I), Representative tumor images, (B, F, J), Kaplan–Meier curves of overall survival, (C, G, K), tumor weight, and (D, H, L) growth curves of each group. Experiments were repeated three times. Scale bar, 1 cm. (M, N) Representative images and quantification for the area of positive CD163, CD8, and NK1.1 staining in subcutaneous tumor models. Scale bar, 50 μm.