FIGURE 7.

Hepatocellular carcinoma (HCC) is one of the most lethal and fastest growing malignancies worldwide. The authors aimed to investigate the differences between patients with HCC based on tumor molecular classification and provide targeted therapeutic options for them. The authors elucidated the cooperation between certain driver genes that leads to different transcriptomic and proteomic profiles, reflecting the intertumor complexity observed in HCC patients and screened out targeted inhibitors of sorafenib‐resistant tumors with different molecular classifications. EZR, ezrin; HCC, hepatocellular carcinoma; NF‐κB, nuclear factor‐κB; STAT3, signal transducer and activator of transcription 3.