FIGURE 1.

SLC3A2 is significantly highly expressed and associated with poor prognosis in lung adenocarcinoma (LUAD). (A) Expression heatmap of 422 SLC family genes in 17 human cancers. Each grid in the heatmap represents the log2 logarithm of the ratio of the expression of this gene in the tumor and the adjacent normal tissue. SLC family genes are classified into types I–III according to the ratio from low to high. (B) Multivariate Cox analysis results of type III SLC family genes in LUAD. Hazard ratio greater than 1 indicates a risk factor and is associated with poor prognosis. (C, D) Kaplan Meier survival curve of The Cancer Genome Atlas (TCGA) (C) and GSE31210 (D). Patients are divided into high and low expression groups according to the median expression of SLC3A2. (E) Immunohistochemical staining and quantification of SLC3A2 in LUAD and adjacent tissues. Representative images are enlarged in the right panel. (a) Normal lung epithelial cells. (b) Macrophages. (c,d) LUAD cells. Scale bar, 50 μm; n = 51. (F) Kaplan–Meier survival curve of 51 LUAD patients. Patients were divided into high and low expression groups according to the median expression of SLC3A2 based on immunohistochemical staining