Table 11.

List of various pharmacological treatments used to manage weight gain associated with antipsychotic drugs

Authors	Design	Duration (weeks)	Group	Age (yrs)	Antipsychotic used	Weight changes (kg)
Deberdt et al.[12]; (2005)	Double blind placebo controlled	16	Amantadine 100-300 mg Placebo	40±12 41±12	Olanzapine	–0.19+1.28
Graham et al.[13]; (2005)	Double blind placebo controlled	12	Amantadine 300 mg/day Placebo	Adult	Olanzapine	–0.36+3.95
Baptista et al.[14]; (2007)	Double blind placebo controlled	12	Metformin 850-2550 mg/day Placebo	44.3 44.6	Olanzapine	–1.4 0.18
Baptista et al.[15]; (2008)	Double blind placebo controlled	12	Metformin 850-2550 mg/day + sibutramine Placebo	45.5 49.3	Olanzapine	–2.8 –1.4
Klein et al.[16]; (2006)	Double blind placebo controlled	16	Metformin 250-850 mg/day Placebo	12.9 13.3	Olanzapine, Risperidone	–0.13+4.01
Atmaca et al.[17]; (2003)	Double blind placebo controlled	8	Nizatidine 150 mg bd Placebo	27.1 28.7	Olanzapine	–4.5+2.3
Chengappa et al.[18]; (2007)	Double blind placebo controlled	8	Topiramate 300 mg/day placebo	42.6 42.8	Valproate	–1.49+2.72
Our study	Open-labeled randomized controlled	8	Acetazolamide	37.76 45.29	Risperidone and Olanzapine	–0.57+2.62