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. 2023 Jun 1;11:88. doi: 10.1186/s40478-023-01584-z

Table 2.

The distribution and severity of tau lesions (Case 1)

Region NFT & pre-NFT Coiled bodies Tufted astrocytes Astrocytic plaques Other astrocytic lesions Tau+ threads
Temporal cortex +++ + ++ + ++
Superior frontal gyrus +++ ++ + +++ + +++
Motor cortex +++ ++ +++ + +++
Caudate/putamen +++ ++ + +++ + +++
Globus pallidus ++ ++ ++
Basal nucleus ++ + +++
Hypothalamus +++ + +++
Ventral thalamus +++ + + ++
Subthalamic nucleus +++ + +++
Thalamic fasciculus ++ ++
Red nucleus + ++ ++
Substantia nigra ++ + +++
Oculomotor complex ++ + + ++
Midbrain tectum ++ ++ ++ + +++
Locus ceruleus +++ +++
Pontine tegmentum ++ + ++
Pontine base + + +
Medullary tegmentum +++ + +++
Inferior olivary nucleus + ++ +
Dentate nucleus ++ +++
Cerebellar white matter ++ +

Some astrocytic tau lesions are hardly categorized into either tufted astrocyte or astrocytic plaques, which are categorized as other astrocytic lesions. NFT neurofibrillary tangle