Table 2.
The distribution and severity of tau lesions (Case 1)
| Region | NFT & pre-NFT | Coiled bodies | Tufted astrocytes | Astrocytic plaques | Other astrocytic lesions | Tau+ threads |
|---|---|---|---|---|---|---|
| Temporal cortex | +++ | + | − | ++ | + | ++ |
| Superior frontal gyrus | +++ | ++ | + | +++ | + | +++ |
| Motor cortex | +++ | ++ | +++ | − | + | +++ |
| Caudate/putamen | +++ | ++ | + | +++ | + | +++ |
| Globus pallidus | ++ | ++ | − | − | − | ++ |
| Basal nucleus | ++ | + | − | − | − | +++ |
| Hypothalamus | +++ | + | − | − | − | +++ |
| Ventral thalamus | +++ | + | + | − | − | ++ |
| Subthalamic nucleus | +++ | + | − | − | − | +++ |
| Thalamic fasciculus | − | ++ | − | − | − | ++ |
| Red nucleus | + | ++ | − | − | − | ++ |
| Substantia nigra | ++ | + | − | − | − | +++ |
| Oculomotor complex | ++ | + | − | − | + | ++ |
| Midbrain tectum | ++ | ++ | ++ | + | − | +++ |
| Locus ceruleus | +++ | − | − | − | − | +++ |
| Pontine tegmentum | ++ | + | − | − | − | ++ |
| Pontine base | + | + | − | − | − | + |
| Medullary tegmentum | +++ | + | − | − | − | +++ |
| Inferior olivary nucleus | − | + | ++ | − | − | + |
| Dentate nucleus | ++ | − | − | − | − | +++ |
| Cerebellar white matter | − | ++ | − | − | − | + |
Some astrocytic tau lesions are hardly categorized into either tufted astrocyte or astrocytic plaques, which are categorized as other astrocytic lesions. NFT neurofibrillary tangle