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The structure and function of EZH2. A. The EZH2 gene is situated at the chromosomal locus 7q36.1 and has been found to encode five distinct isoforms of the protein. The amino acid lengths of five isoforms are illustrated in the figure. Schematic domain structures of EZH2 isoform A are shown, including SBD, EBD, BAM, SAL, SRM, SANT1, MCSS, SANT2, CXC, and SET. B. EZH2 mediates transcriptional silencing and regulates protein activity by methylating both histone and non-histone substrates
